Overexpression of angiopoietin-1 reduces doxorubicin-induced apoptosis in cardiomyocytes

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Overexpression of angiopoietin-1 reduces doxorubicin-induced apoptosis in cardiomyocytes

Doxorubicin (Dox) is a major anticancer chemotherapeutic agent. However, it causes cardiomyopathy due to the side effect of cardiomyocyte apoptosis. We have previously reported that angiopoietin-1 significantly reduced myocardial infarction after ischemic injury and protected cardiomyocytes from oxidative stress-induced apoptosis. It is hypothesized that angiopoietin-1 may protect cardiomyocyte...

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ژورنال

عنوان ژورنال: Journal of Biomedical Research

سال: 2012

ISSN: 1674-8301

DOI: 10.7555/jbr.26.20120006